Anti-sleeping Pills - Types, Benefits, Side Effects

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Sleep is a crucial aspect of a healthy lifestyle. However, modern fast living has often posed several struggles in getting quality sleep every day. While it may seem sleeping pills would be the most discernible way to get quality sleep, anti-sleeping pills are equally, if not more, important for obtaining a healthy sleep-wake cycle in our daily lives.

To help you in having a better grasp on your sleep-wake cycle, in this blog, we shall discuss some of the most effective anti-sleeping pills available in the market, how they work, how to use them, and their side effects.

What are Anti-sleeping Pills?

Anti-sleeping pills are exactly what they are called, these are medications that promote wakefulness, or help you stay awake by somehow altering biochemical reactions within the body. Most anti-sleeping pills available to us at the moment work by manipulating brain chemistry. All of them were initially developed to treat sleeping disorders but were later found to have a beneficial effect of positively modifying the sleep cycle.

However, as all anti-sleep substances are brain stimulators, off-label use of them is not encouraged anywhere. You would require a physician’s prescription to use any of these pills on a regular basis to fix your sleeping habit. Of these, Modafinil is the safest and most effective anti-sleep pill. Due to its popularity and safety, it is possible to buy modafinil online for regular use, without a prescription.

Types of Anti-Sleeping Pills

As I have already mentioned, there are only a handful of FDA-approved anti-sleeping agents available to us. In the following, we have a list of the safest and most effective anti-sleep substances that you can use for fixing your sleep cycle.


Modafinil is a eugeroic drug that works as a wakefulness-promoting agent by altering the amount of dopamine present in the body. It acts as an inhibitor of dopamine reuptake receptors in the neural junctions which slows down the reuptake process of dopamine. This in turn increases the amount of dopamine available in the neural junctions. Dopamine is a neurotransmitter that promotes alertness, focus, memory, and cognition, among the other things it performs in the body. By increasing the amount of dopamine in the body, Modafinil succeeds in prolonging its effects, thus increasing focus and alertness in you.


Armodafinil is a form of modafinil that was designed to have a longer half-life in our bodies. This ensures that armodafinil acts in the body for a longer time than modafinil. Aside from this, armodafinil works in an identical mechanism as modafinil. Most bioactive compounds have enantiomers. Enantiomers of a compound are exactly identical in structure except for the fact that spacially, they are mirror images of each other. As result, compounds appear in two enantiomeric forms, L-enantiomer and R-enantiomer. The drug modafinil is a mixture of L-modafinil and R-modafinil, whereas armodafinil is made of pure R-modafinil.


Xyrem is the brand name of the substance sodium oxybate. Much like modafinil, Xyrem is used for the treatment of narcolepsy as it prevents sleep. The exact biomechanics of sodium oxybate in the body is yet to be elucidated by researchers. Xyrem is a gamma-hydroxybutyrate (GHB) salt. Gamma-hydroxybutyrate acid, commonly called GABA, is an important neurotransmitter, like dopamine. However, while dopamine acts as an excitatory neurotransmitter, GABA has inhibitory effects on the brain. In simpler terms, if dopamine switches on your brain, GABA switches it off. It is projected that as a GABA-like molecule, GHB imitates GABA in the body to bind to GABA receptors, prohibiting GABA to act on the body.


Caffeine is a component of the popular beverage coffee and is mostly consumed in the form of coffee itself. The use of caffeine pills is not that popular although they are available. Caffeine is also consumed in the form of energy drinks. Caffeine works as a brain stimulant by increasing dopamine release in the body. Not just dopamine, caffeine generally increases the level of a group of neurotransmitters called noradrenergic molecules. These molecules are responsible for stimulating the brain to stay awake and focused. In this, way, caffeine promotes alertness in the body.


Methylphenidate (MPH) has a very similar mode of mechanism to modafinil. It also increases the amount of dopamine in the body by inhibiting dopamine reuptake receptors from removing dopamine from the neural synapses. Although similar in action, MPH and modafinil have vastly different chemical structures, as a result of which, MPH is a very strong CNS stimulant. Initially developed as a treatment drug for ADHD, MPH, commonly sold under the brand name Ritalin, is categorized as a narcotic with high liabilities for dependency and addiction.

Eugeroics vs. other CNS Stimulants

Now that we are familiarized with the most common anti-sleeping pills we can get our hands on, it is crucial that we also discuss the safety factors as well as the effectiveness of these drugs.
In terms of effectiveness, Ritalin is the most effective anti-sleep pill, closely followed by Armodafinil and Modafinil, then caffeine, and lastly, Xyrem. Simultaneously, in terms of safety, the safest pills are armodafinil and modafinil, followed by caffeine. Ritalin and Xyrem are both active narcotics with substantial addiction liabilities. Caffeine does have some dependency risks and also runs an elevated risk of tachycardia and other side effects due to overdose.

Based on this comparison, it is easy to conclude that Modafinil and Armodafinil are the best anti-sleep pills available on the market.

Benefits of Anti Sleeping Pills

Although originally developed for the treatment of neurological disorders like narcolepsy and ADHD, anti-sleeping pills are now widely popular for their capacity to prevent sleep. Here are three important benefits of anti-sleeping pills that are good for even healthy individuals.

  1. Fixes the sleep-wake cycle : Our present lifestyle often causes disruption of the normal sleep-wake cycle of the body. This occurs due to stress, untimely napping, sedentary lifestyles, overworking, and several other lifestyle reasons. To get rid of an unhealthy sleep cycle, it is important to control the time, quality, and amount of sleep regularly. Anti-sleep pills can help fix our sleep cycles by keeping us awake during work hours so that we can sleep well at bedtime.
  2. Increases focus : Because all of the anti-sleep medications we discussed, with the exception of Xyrem, are brain stimulants, they also improve our ability to focus or be more attentive. This, in turn, can help us be more productive at work and get more done in a shorter time span.
  3. Increases cognitive capacity : CNS stimulants like modafinil, armodafinil, and MPH are known to have nootropic effects on our brains. These drugs increase the amount of dopamine in our bodies. Dopamine is widely known to improve cognitive abilities. In this way, these anti-sleep drugs end up having nootropic effects on us.

Potential Side Effects of Anti-sleeping Pills

As I have briefly mentioned previously, most of the anti-sleep pills we discussed here come with their own risks.

  • Ritalin is a narcotic with high risks of addiction and dependence and therefore high chances of drug abuse.
  • Because of its popularity as a street drug, Xyrem is also a narcotic whose distribution is strictly controlled.
  • Caffeine is comparatively safer than the above two, but an overdose of caffeine can have really unpleasant effects.
  • Modafinil and armodafinil have no prominent side effects or risks of dependency and addiction.

The following table shows all the common side effects of the anti-sleep pills under discussion.

Anti sleeping pills common side effects

Final Words

To wrap things up, we discussed the most common anti-sleep pills available to us, that you can use to fix your sleep cycle and return to a normal, healthy lifestyle. Although I hope this blog would help you choose an anti-sleep pill suitable for your needs, it is still wise to seek physician advice before taking any of these medications. From this discussion, It can also be said that modafinil and armodafinil are the safest and most effective anti-sleep pills available at the moment.

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